In addition, drops used for 1 week on patients with culture-positive otorrhea were analyzed for contamination of both the bottle teat and the drop solution. Bottles were also assessed for contamination once opened. Their effectiveness was assessed on agar plates inoculated with both Staphylococcus aureus and Pseudomonas aeruginosa. We aimed to determine appropriate recommendations for the shelf life of common antibiotic-containing topical otic solutions.Įar drops containing gentamicin and ciprofloxacin were analyzed. The advice given to patients regarding the shelf life of antimicrobial ear drops is based on little or no evidence.
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